back Glonoinum

Common name. - Nitro-Glycerine. Preparation. A tincture made by dissolving one part of Nitro-Glycerine in nine parts of alcohol, which corresponds to the lx dilution. Subsequent dilutions with alcohol.


Acts upon the medulla oblongata and the pneumogastric, and paralyzing the peripheral vaso-motor nerves, producing active (Amyl nitrite, passive) cerebral hyperemia and palpitation of the heart, the former presenting symptoms closely resembling those resulting from exposure to the sun's rays, even to the intense degree of sunstroke, yet lacking the important symptoms of fever and inflammation which characterize cerebral disorders caused by Aconite and Belladonna. Its action is not so evanescent as that of Amyl nitrite. The chief characteristic of Glonoine is a pulsating, throbbing fullness (not pain) in the brain.


Mind.- Falling down, with loss of consciousness and alternate palpitation of the heart and congestion of the head. Confusion of ideas (Bapt., Gels., Phos. ac.); cannot tell where he was; well-known streets seem strange; the way home too long; forgets on which side of the street he lives.

Head.- Vertigo; worse from stooping or moving the head (Bry.); worse in the open air; with nausea; with dim vision. Inclination to bend the head backwards, or to hold it with the hands. Sensation as if the head were enormously large (Arg. nit., Bovis., Cimic, Zing.). Fullness in the head; distinct feeling of the pulse in the head (Bell.); throbbing without pain. Sensation as if the blood wer& mounting to the head (Bell.); as if hanging head down- ward. Tensive pain over the eyes and nose, also behind the ears, followed by choking sensation about the throat. Skull seems too small, as if the brain were attempting to burst the skull (Cimic.); violent action of the heart, and a distinct pulsation over the whole body. Sensation of soreness through the whole head; is afraid to shake the head, as it seems that it would make the head drop to pieces. Throbbing in the head; in forehead; in temples; in vertex; in occiput; worse when moving (Bry.)\ better when sitting still and lying and from pressure (Bell.), Cracking sensation in the brain. Shocks in the brain synchronous with the pulse. Undulating or wave-like motion in the brain ( Cinch.). Throbbing in the temporal arteries, which were raised and felt like cords (Bell.). Severe pain in the occiput; extending to the eyes and temples. Congestion in occiput, seems as if he would lose his reason. Headache deep in the brain; rising from below upward; extending to nose. Headache and pulse increase and diminish together. Headache with nausea; with dull heavy pain in stomach. Headache aggravated mornings and forenoons. Shaking the head increases the headache; also motion (Bry.). Headache worse from the heat of the sun (Bell., Natr. carb.); better in the open air and from pressure. oHeadache, throbbing, etc., during or in place of menses (Cinch.).

Eyes.- Sparks a,nd flashes before the eyes, (Bell., Cycl.); black spots on attempting to stoop. Objects dance with every pulsation. Pressing, protruding pains in eyes. Eyes injected, protruding, look wild (Bell., Hyos.). Pupils di- lated, eyes rolled upward (Bell.).

Ears.- Deafness, ears feel as if stopped up (Coni.). Kinging in the ears, audible pulse.

Pace. - oPale during heat, sunstroke, congestion, etc.; flushed and hot with headache. Kedness of the face, which comes and goes. Gnawing pain in the masseter muscles.

Mouth. - Throbbing pain in all the teeth.

Throat.- Itching of the soft palate and throat. Sensation as if the throat were swelling.

Stomach.- Increased desire to smoke. oNausea and vomiting in congestion or during sunstroke. Eructations. Nausea. Faint feeling at pit of stomach , also with throbbing.

Abdomen. - Rumbling, with feeling as before diarrhoea.

Female Organs. - oInstead of menses congestion to head; face pale; worse in warm room; fainting; throbbing. oAt climaxis, flushes of heat, pressure in head, nausea, loss of senses, vertigo, swelling of feet. oEclampsia; unconscious; face bright-red; puffed; pulse full, hard; urine copious and albuminous.

Respiratory Organs. - Inclination to deep respiration. Constriction and oppression of the chest.

Heart and Pulse.- Violent action of the heart, distinct pulsation over the whole body. Excessive perceptible palpitation of the heart (Spig.). Pulse accelerated; rises and falls alternately; olow and feeble in sunstroke. Pulse rapid when walking; during headache; full pulse. Laborious action of the heart, oppression. Sharp pains in heart; on stooping; extending to between the shoulders. Purring noise in region of heart when lying, pulse intermittent.

Neck.- Tightness around the neck. Cramp in nape of neck. Hot sensations down back. Pain down entire spine.

Generalities.- Great weakness and prostration (Ars., Bry., Cinch., Phos.). Painless throbbing in the whole body (Ant. crud., Puls., Sil., Sep., Zinc). Seeming plethora, rapid deviations in distributions of blood. Falling down unconscious, with convulsions and frothing at mouth, after alternations of palpitation and congestion to head.

Fever.- Warmth general; flushes of heat; waves of heat upward. Profuse sweat, mostly on face and chest.

Compare.- Acon., Amyl nit., Bell., Brom., Bry., Cactus, Coff., N'atr. carb., Nux v., Stram.

Antidotes. - Acon., Camph., Coll., Nux v.


Glonoine is a valuable remedy in cerebral congestions, especially when resulting from exposure to the rays of the sun, or from mental excitement, fright or fear. In such cases the face is pale; and, while there is a severe bursting or crushing pain, the chief characteristic is a throbbing or pulsation all through the head with every beat of the pulse, but which is not painful, and a sort of undulating or wave-like motion in the brain. Sometimes the attacks come on suddenly, the patient becomes dizzy and loses his way, perhaps falls down unconscious. These symptoms may be hemicrania, or threaten an attack of apoplexia, or, occurring from exposure to the sun's rays, if continued, result in sunstroke, in which Glonoine is a most efficient remedy if the symptoms correspond as they frequently do. (Compare Bell., Natr. c). Cerebro-spinal meningitis. Cerebral congestions from suppressed menses. Hydrocephalus. The mental symptoms of Glonoine may result from mental shock, or from mechanical injuries, or their later consequences, or from exposure to the sun's rays, but they are usually associated with more or less of the cerebral symptoms mentioned. Also pains and other sensations long after injuries. Familiar things seeming strange, and the patient loses his way are very characteristic. Acute mania. Insanity. Useful in supra-orbital neuralgia, also in neuralgia of the face, extending through the head, with painless throbbing. According to Farrington, Glonoine is useful in retinal congestions, even apoplexia from exposure to a bright light. Sometimes in sea-sickness with characteristic cerebral symptoms. Glonoine is frequently a remedy for epileptiform convulsions, falling down unconscious with frothing at the mouth; puerperpal convulsions. Allen recommends Glonoine in Angina pectoris, where there is fluttering of the heart and violent beating, as if it would burst the chest open, with labored breathing, pains radiating in all directions, even into the arms, with loss of power in the arm.

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